| C.J. Stroud | HOU | 5135 | Bryce Young | CAR | 3781 | Anthony Richardson | IND | 3390 | Malik Cunningham | NE | 2061 | Stetson Bennett IV | LAR | 400 |
| Bijan Robinson | ATL | 2100 | De'Von Achane | MIA | 952 | Keaton Mitchell | NE | 844 | Zach Evans | LAR | 454 | Jahmyr Gibbs | DET | 220 |
| Tank Dell | HOU | 1442 | Jayden Reed | GB | 1078 | Jordan Addison | MIN | 969 | Jonathan Mingo | CAR | 873 | Jaxon Smith-Njigba | SEA | 845 |
| Michael Mayer | LV | 760 | Sam LaPorta | DET | 688 | Luke Musgrave | GB | 217 | Dalton Kincaid | BUF | 128 | Brenton Strange | JAX | 77 |
Defensive Leaders
| Byron Young | LAR | 5.0 | Mazi Smith | DAL | 4.0 | Julius Brents | IND | 3.0 | Myles Murphy | CIN | 2.5 | Jalen Carter | PHI | 2.0 |
| Brian Branch | DET | 75 | Deonte Banks | NYG | 65 | Devon Witherspoon | SEA | 53 | Joey Porter Jr | PIT | 47 | Marte Mapu | NE | 47 |
| Deonte Banks | NYG | 3 | Julius Brents | IND | 2 | Jartavius Martin | WAS | 2 | Devon Witherspoon | SEA | 2 | DeMarvion Overshown | DAL | 1 |
| DeMarvion Overshown | DAL | 1 | Marte Mapu | NE | 1 | Henry To'oTo'o | HOU | 0 | Will Anderson Jr | HOU | 0 | Jordan Battle | CIN | 0 |
Special Teams Leaders
| Chad Ryland | NE | 95 | Jake Moody | SF | 93 | Anders Carlson | GB | 54 | Tanner Brown | DEN | 26 | Jack Podlesny | TEN | 22 |
| Bryce Baringer | NE | 2321 | Ethan Evans | LAR | 1611 | Brad Robbins | CIN | 1404 |